Linda Wilbert-Stewart, FDN, HHP, Contributor
Thyroid Nation

What You Should Know about Pyroluria, Anxiety, and Mood Swings

What exactly is Pyroluria? Well, Pyroluria which is also called Kryptopyroluria or Pyrrole disorder, is a by­products of hemoglobin synthesis. Pyroluria is a condition whereby more than the normal amounts of Pyrrole molecules are produced. Pyrroles are excreted through the urine, which makes testing for Pyroluria very easy.

There are some basic symptoms of Pyroluria you may want to consider and these include:

  • Depression
  • Anxiety
  • Mood swings
  • Hyperactivity
  • Noise sensitivity
  • Sensitive to bright light
  • Poor stress adaptation
  • Obsessive ­compulsive behavior
  • White spot on fingernails
  • Insomnia
  • No dream recall
  • Loss of appetite in the mornings
  • Poor memory
  • Brain fog
  • Dry skin
  • Suffer often from infections

As noted above, Pyrroles are excreted through the urine and because Pyrroles bind to zinc and vitamin B6, both are also excreted through urine. This leads to a deficiency of both zinc and vitamin B6.

When we look at the role of vitamin B6 and zinc, we can find that they are both important cofactors in methylation processes.

ExclusivelyHolistic-AdA higher incidence of Pyrrole disorder is found in individuals with:

  • Autism spectrum. It is also found in individuals with
  • Anxiety disorder
  • Depression
  • Obsessive­compulsive disorder
  • Schizophrenia
  • Bipolar disorder
  • Aspergers
  • ADHD

The severity of the symptoms of Pyroluria depends on different factors and can range from very mild to very severe. It is unfortunate that physicians usually do not test their patients for Pyroluria simply because they either do not know about it or they do not believe in it. Instead their patients receive a prescription for antidepressants. Yet, the underlying cause has not been addressed in any way and the suffering of patients continues needlessly. Today, numerous studies have been conducted on this condition and can be easily accessed online.

We need to be cautious when we start supplementing with zinc simply because it can lead to low copper. We need to be mindful when we start taking any mineral because it can influence other minerals and can cause a mineral imbalance. When this happens, we end up with even more problems than before. This is why a Hair Tissue Mineral Analysis is always recommended when the test for Pyroluria is positive.

Important Lab Tests to Order:


Use code THY_NATION for $10 off.

In addition, if you are feeling worse on fish oil, then you should consider getting tested for Pyroluria. Vitamin B6 as P5P and Zinc supplementation can be very helpful, but they need to be monitored carefully in conjunction with symptom changes.

Here is a CHECKLIST of some common signs and symptoms of pyroluria:

Most Common Signs and Symptoms Checklist

1. Being anxious, shy, or fearful or experiencing inner tension since childhood, but hiding these feelings from others
2. Having bouts of depression or nervous exhaustion
3. Poor dream recall, stressful or bizarre dreams, or nightmares (low vitamin B6)
4. Excessive reactions to tranquilizers, barbiturates, alcohol, or other drugs, in which a little produces a powerful response (low vitamin B6)
5. Preferring not to eat breakfast, experiencing light nausea in the morning, or being prone to motion sickness (low vitamin B6)
6. White spots or flecks on the fingernails or opaquely white or paper-thin nails (low zinc)
7. Liquid zinc sulfate having a mild taste or tasting like water (low zinc)
8. Poor appetite or having a poor sense of smell or taste (low zinc)
9. Joints popping, cracking, or aching; pain or discomfort between the shoulder blades; or cartilage problems (low zinc)
10. Pale or fair skin or being the palest in the family, or sunburning easily, now or when younger
11. Disliking protein or having ever been a vegetarian or vegan
12. Being sensitive to bright sunlight or noise
13. Upper abdominal pain on your left side under the ribs or, as a child, having a stitch in your side as you ran
14. Frequent fatigue
15. Being prone to iron anemia or low ferritin levels
16. Tending to have cold hands or feet
17. Having frequent colds or infections, or unexplained chills or fever
18. Reaching puberty later than normal or having irregular menstruation or PMS
19. Having allergies, adrenal issues, or problems with sugar metabolism
20. Having gluten sensitivity
21. Neurotransmitter imbalances, especially low serotonin
22. For women, belonging to an all-girl family or having look-alike sisters
23. For men, having a mother from an all-girl family or a mother with look-alike sisters, or all the females in the mother’s family bearing a strong resemblance to each other
24. Avoiding stress because it upsets your emotional balance
25. Tending to become dependent on one person whom you build your life around
26. Preferring the company of one or two close friends rather than a gathering of friends; becoming more of a loner as you age
27. Feeling uncomfortable with strangers
28. Being bothered by being seated in the middle of the room in a restaurant
29. Being easily upset by criticism

Less Common Signs and Symptoms

30. Stretch marks or poor wound healing (low zinc)
31. Crowded upper front teeth, many cavities, or inflamed gums or wearing braces (low zinc)
32. Bad breath and body odor (or a sweet, fruity odor), especially when ill or stressed (low zinc)
33. Being prone to acne, eczema, herpes, or psoriasis
34. Reduced amount of hair on your head, eyebrows, or eyelashes, or prematurely gray hair
35. Difficultly recalling past events and people in your life
36. Focusing internally, on yourself, rather than on the external world
37. Tending to have morning constipation
38. Tingling sensations or muscle spasms in your legs or arms
39. Feeling stressed by changes in your routine, such as traveling or being in new situations
40. Your face looking swollen when you’re under a lot of stress
41. Cluster headaches or blinding headaches
42. One or more of the following: a psychiatric disorder, schizophrenia, high or low histamine, alcoholism, learning and behavioral disorders, autism, or Down syndrome

UltraLabBannerAdIf you check off 15 or more items, especially the more common ones, it’s highly probable that you may suffer with pyroluria. It is important that you get tested.

Email me if you would like to book a 20 minute Consultation and or would like to get tested.

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About the Author

LindaExHolNEW-profileLinda Wilbert – Stewart, FDN, HHP is a Certified Functional Diagnostic Practitioner and Certified Holistic Health Practitioner with diplomas from the Natural Healing College. She is a Certified Health Coach from Beyond Organic University. She took classes in Functional Blood Chemistry. Module one and two MTHFR, Methylation & Biochemistry master course. She graduated in Germany as an Occupational Therapist in 1988. Linda uses functional diagnostic lab tests to find underlying causes of symptoms. Check out her website, to get a Free Health Consultation and get her Free eBook, here. Please be sure to follow her on Facebook.  Shop amazing probiotics, here.

Questions or anything to add about pyroluria and thyroid anxiety? We want your thoughts in the comments section–Please! 

-Vitamin B6 nutritional status of a psychiatric outpatient population
-A Sohler, CC Pfeiffer ­ J Orthomolec Psychiatr, 1982 ­
-The discovery of kryptopyrrole and its importance in diagnosis of biochemical imbalances in schizophrenia and in criminal behavior
-A Hoffer Children, 1995­
-Pharmacol Biochem Behav. 1975 Mar­Apr;3(2):243­50.
-Neurological and behavioral toxicity of kryptopyrrole in the rat
-Walker JL. Nature. 1969 Nov 22;224(5221):811­3. Identification of kryptopyrrole in human urine and its relation to psychosis.
-Irvine DG, Bayne W, Miyashita H, Majer JR. Trudy Scott (CN), Certified Nutritionist, founder