Dr. Will Cole, Guest
Thyroid Nation

High Homocysteine Levels And Autoimmune Disease

Although 50 million Americans suffer from autoimmune diseases, mainstream medicine is largely reactive, offering only pharmaceuticals when your problem gets bad enough. Despite spending trillions of dollars on autoimmune conditions, we’re sicker than ever. There’s very little that’s “healthy” about our current healthcare system. Let’s start calling it what it is: “disease management” or “sick care system.”

We need to start looking at sustainable natural solutions for these chronic autoimmune problems. But it’s also important to know your risk factors early so you can prevent the problems in the first place!

Functional medicine practitioners are concerned with just that. We find the pieces of the autoimmune puzzle and tailor a comprehensive natural health plan to the individual’s specific needs.

There’s one lab that serves as both a risk factor indicator and an effect of autoimmunity. A simple blood lab called a homocysteine test is one that I recommend for all of my patients around the world, but especially for my autoimmune patients.

What is Homocysteine?

Homocysteine is an amino acid produced in the body. It’s normal to have homocysteine, but high levels are linked to autoimmune conditions.

What makes homocysteine high?

Stress, poor diet and toxins can all raise homocysteine levels in the body. A process called methylation is needed to keep your body healthy and homocysteine in check. To have healthy methylation pathways, your body needs beneficial methyl donors, namely B vitamins from the foods you eat, which convert homocysteine to SAMe and glutathione.

SAMe increases the availability of the neurotransmitters serotonin and dopamine, and protects your nerves. Glutathione is your body’s strongest antioxidant. Both are essential for putting autoimmune reactions into remission. When your methyl donors are lacking, homocysteine accumulates in the body.

Homocysteine can also increase with estrogen deficiency, and with some long term medications given to autoimmune patients. Strict vegetarians and vegans can also be prone to methylation impairments due to a potential deficiency of vitamin B12. These are just some of the factors that can raise homocysteine.

Autoimmune-Homocysteine Connection

Healthy methylation pathways and balanced homocysteine levels protect your DNA. Methylation keeps good genes turned on and bad genes turned off. Conversely, methylation impairment is a key finding in autoimmune conditions, and can trigger an autoimmune response.

High levels can also be a consequence of poor absorption of B vitamins, which is needed for methylation pathways.

Homocysteine & The Brain

Homocysteine levels above 7 UMOL/L have been shown to damage the protective blood-brain barrier (leaky brain syndrome), and are linked to autoimmune spectrum diseases like Alzheimer’s. More than 5.4 million people in the US have Alzheimer’s disease, and by the year 2050, it’s estimated that up to 16 million Americans will have it.

Protecting your brain, neurotransmitters and myelin are key factors in reversing and preventing autoimmune decline. All of these depend on healthy methylation pathways.

Homocysteine & The Heart

High homocysteine levels are linked with cardiovascular damage, and heart disease is the leading cause of death for both men and women. Many autoimmune conditions, such as lupus and autoimmune thyroid disease (Hashimoto’s or Graves), increase the risk for heart attack and stroke. Protecting the heart is of utmost importance to anyone, especially someone with higher risks.

What to do now?

Another lab to run in conjunction with measuring homocysteine is a MTHFR genetic mutation test. The more gene polymorphisms you have, the more methylation impairments you’re likely to experience, which leads to higher levels. This genetic predisposition is found in many autoimmune cases, such as Hashimoto’s. Knowing your risk factors is the first step to optimizing your health.

In addition to homocysteine and MTHFR mutation tests, there are several other labs I recommend for optimal DNA health!

Important Lab Tests to Order:


Use code THY_NATION for $10 off.

If you have high homocysteine levels or an autoimmune condition, the type of B vitamins you take is important. Be sure to go for the activated forms of folate, B6 and B12:

  • L-5-MTHF Folate: Methylfolate
  • B6: Pyridoxyl-5-Phosphate (P5P)
  • B12: Methylcobalamine
Methylation impairment is a key finding in autoimmune conditions, and can trigger an autoimmune response. Click To Tweet

Implementing a variety of natural tools to promote immune balance is another way to put autoimmune symptoms into remission.

Stay up-to-date, get tips, articles and stories that inspire, on all things thyroid!

About the Author

dr-will-cole-functional-medicine-expert-and-practionerDr. William Cole, DC, graduated from Southern California University of Health Sciences in Los Angeles, California. He has his post doctorate education and training in Functional Medicine and Clinical Nutrition. Dr. Cole consults in the Pittsburgh area and phone or webcam consultations for people around the world. He specializes in clinically investigating underlying factors and customizing health programs for chronic conditions such as thyroid issues, autoimmune, hormonal dysfunctions, digestive disorders, diabetes, heart disease and fibromyalgia. Visit Drwillcole.com for more information and subscribe to his free monthly Future Health Newsletter to stay plugged in with healthy tips and recipes.

PLEASE take a moment to ‘Like’ us on Facebook and follow us on Twitter and Pinterest. You can also listen to Tiffany and I on Thyroid Nation RADIO, every Sunday.

Questions or anything to add about autoimmune disease?  We want your thoughts and questions…spill it!